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Possible spoiler

My following suggestion is unproven as I have not been in the situation of losing Da Vinci before receiving the Nostradamus quest but I hope it helps ...

Have you spoken to Lucius in Montaillou? This should trigger the Rescue the People of Toulouse quest.

I'd suggest that you ...

It is possible that the "+" you are clicking on is the indicator for a "Tag" skill. That "+" is located above a skill icon. Try the "+" next to the number indicating the actual skill points.

Good luck