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How do I enter the doors to get to rooms 2 and 3 in Irenicus Level 2? When I try to get through they are locked. Also, how do I destroy the portals to prevent more mephits from entering? I've entered room 1 and fought with the Memphits, I've also found the wand of fire, wand of summoning, and wand of cloudkill key.

You simply attack the portals to get rid of them. IIRC the doors shouldn't be locked, or maybe there's a key you were supposed to pick up, but anyways, if you have questions the walkthrough is always really helpful.
http://gamebanshee.com/baldursgateii/lo ... rison2.php