I doubt movie-grain will cause something like that. Based on that screenshot, it does look a lot more serious than some in-game graphical option issue. Maybe try to update your graphic drivers but if this problem occur after a driver upgrade, then maybe reverting back to an older driver might help.
''They say truth is the first casualty of war. But who defines what's true? Truth is just a matter of perspective. The duty of every soldier is to protect the innocent, and sometimes that means preserving the lie of good and evil, that war isn't just natural selection played out on a grand scale. The only truth I found is that the world we live in is a giant tinderbox. All it takes...is someone to light the match" - Captain Price
Hm. For some reason, uninstalling and reinstalling minus my "Bring Down The Sky" DLC made the graphics go right. Now I'm worried to reintroduce the DLC to the game.
There's a bug in the patch that comes with the DLC that messes up the shader cache. You can fix it by going to My Documents\BioWare\Mass Effect\Published\CookedPC and deleting the UPK file (LocalShaderCache-PC-D3D-SM3.upk).
There are 10 types of people in the world - those who understand binary and those who don't. I think I think, therefore I might be.