Anyway, my question for anybody who's played all the way through in Hardcore mode: are there any branches of the main quest line that are significantly easier or harder than the others in Hardcore mode? I've finished the main quest in Normal mode at least once for each of the factions so I have some ideas, but considering how different the game has been just getting to The Strip, I'm a bit concerned that there may be tactical difficulties later on that I haven't anticipated.
Among the things I have anticipated: (Minor spoilers)
Spoiler
since stimpaks don't heal you immediately, destroying the Brotherhood bunker seems like a suicide mission, and stand-up fights against the Legion don't seem much better, so I'm leaning toward helping Yes Man and keeping my reputation with everybody else at least neutral for as long as possible.