I just bought a second copy of Bloodlines. I am wondering if I can just update with the initial official patch and the newest patch or do I have to update all the patches 1.1-9 to 2.1-3.
Official patch, then the latest unofficial. There's no need to apply the unofficial patches in sequential order. Each one includes/modifies the previous ones.
".... for I had seen the Human face of the Vampires, and now I beheld the monstrousness of these Men..."