GameSpot's Best of 2010 Awards
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Borderlands: The Secret Armory of General Knoxx: Best DLC
Dragon Age: Origins - Witch Hunt: Worst DLC for a Good Game
Mass Effect 2: Best RPG
Warhammer 40,000: Dawn of War II - Chaos Rising: Best Expansion Pack
It looks like they haven't revealed their overall Game of the Year, so I'll update this post if it happens to be Mass Effect 2.