I must say I have some disappointments.
1. For a fallout series, there wasn't really all that much sex, drugs, and vices. There wasn't even any romance at all.
2. The game seemed to lack the dry humor previous series had.
3. I didn't get any traveling companions till really late in the game.
4. Dying at the end is kinda sad. But what makes it so illogical is flak (the super mutant) was with me, but REFUSES to turn on the purifier in my stead when he is IMMUNE to the high radiation within, on the basis that 'its my destiny'... Oh man...
5. In previous fo series, the ending gave detailed aftermaths of each individual major town based on what you've done there, the ending in fo3 doesn't mention any of this...