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1 - Cross
If you use mana at all, break the cross with the
Scepter of Chambers as soon as you enter the dungeon.
2 - Renaldo
If you have the potion from Bartolome, you can use it on Renaldo to free him (150 experience).
3 - Daeva of Pain
He'll ask you to do two things: Lure Faust to him (if you haven't freed Faust already) and free him by breaking the two crosses nearby. If you do either you'll receive 450 experience and the Debt of Brimstone perk (+1 critical chance, +5 to your Tribal Necromancy branch, -250 karma). Because of the karma penalty, it's best to wait on this perk until you're not planning to visit Alvaro (the merchant in the Crossroads) any more. You can also attack the Daeva for minor experience and some funny comments.
4 - Galileo
You can offer to rescue Galileo, but he won't want to go. However, he will offer to teach you about the magic arts, provided you free Faust from his prison upstairs. If you do, you'll receive Galileo's Magical Battery, which is worth +50 mana (150 experience). You can also tell Galileo about Hector, the grumpy port guard (150 experience). Finally, if you're talking to Galileo because of the Wielder initiation quest, you need to select the quest dialogue option (marked with a book) to learn about the spirit in the observatory and to have Galileo cast a spell on you so you can see it.
Exits:
A. Stairs to the Inquisition Chambers.