You won't encounter Grenade Hybrids until around Deck 4, but they're quite commonplace beyond that point. Hybrids are humans who have been infected by the parasitic Annelids, and mutated into monsters in service of the Many. Grenade Hybrids are, as their name indicates, equipped with frag grenades that they'll throw your way, but aren't a major threat by the point they're encountered when compared to other enemies.
Attributes: Medium Hit Points, medium damage, low attack speed, low movement speed
Weaknesses: Anti-Personnel Bullets, Anti-Personnel Shotgun Shells, incendiary damage
Common Loot: Hybrid Organ, Fragmentation Grenades, Soda, Vodka, Nanites, Bullets and Shells
Strategy: Grenade Hybrids are the toughest Hybrids you'll face, though that's not really saying much. Although Grenade Hybrids can on occasion be dangerous, the damage they do isn't as high as you'd expect, and their attack speed is quite low. On top of that, they tend to need several seconds to attack upon initial contact, and are fairly inaccurate, meaning that they're actually a bit less dangerous than Shotgun Hybrids unless they get the drop on you. Due to the fact that they tend to run away rather than engage in melee, they're best taken out from a distance.